6th International Hypothalamic Hamartoma Symposium

6TH INTERNATIONAL SYMPOSIUM ON HYPOTHALMIC HAMARTOMAS

Presented by: Hope for HH and Hospital Sant Joan de Déu Barcelona

September 4-5, 2025, Barcelona, Spain

For 2025, we are focusing on improving functional studies to understand the biology of HH and mechanisms underlying genetic mutations, the progress of surgical treatments and their results, as well as a better understanding of the challenges of comorbidities. Ultimately, our goal is to encourage future collaborations and establish a roadmap to identify priorities that drive both the science and clinical care forward.

HH thought leaders including clinicians, clinical investigators, translational and basic scientists to participate in the symposium. The group is multidisciplinary representing several specialties including adult and pediatric neurology/epilepsy, neurosurgery, psychiatry, neuroradiology, neuropsychology, genetics, endocrinology, epidemiology, cognitive sciences, and pharmacology. Invitees represent leading clinical and translational investigators from across the globe, including the United States, Canada, United Kingdom, France, Belgium, Germany, Brazil, Japan, China, and Australia. Previous meetings were held in Montreal (2001), Marseille (2013), London (2016), Washington, DC (2019), and Calgary (2022).

Symposium Committee

Alexis Arzimanoglou, MD., PhD,
Chair

J Helen Cross, MD., PhD,
Co-Chair

Sessions & Topics

• Background to HH Therapies – Patient Testimony and Scientific Talks
  • Background to HH Therapies and Live QR Code Audience Survey
  • The Journey of a Child with HH Through Treatment and Therapy
  • Genetic Architecture of HH: Identifying New Molecular Therapeutic Targets
  • New Insights into the Physiology of the Epileptogenesis in HH Reveal Potential Pharmacologic Targets
  • Development of Preclinical Mouse Models of HH
  • The Challenge of Gene and Drug Therapy Protocols for HH
  • New Targeted Therapies for HH: Convection-enhanced Delivery to Infuse a Genetic Silencer or Anti-epileptic Agent
• Gap Analysis and future Research Directions
  • Genetics, Comorbidities, and Phenotypes Working Groups
• The Challenge of Hypothalamic Rages
  • The Challenge of Comorbidities
  • Results of Patient and Caregiver Survey on Rage Behaviors
  • Initiation of Rage Behaviors in the Rodent Model
  • Brain Connectivity Changes and Dysregulation of Emotion-Regulation Networks in Epilepsy
  • History and Lessons Learned from Psychological Surgery in Aggression
• Hypothalamic Hamartomas Clinical Recommendation
  • Review and Working Group
• Comparative Effectiveness of Surgical Treatments Used in HH: A Systematic Review
  • A Comprehensive Review
  • Direct Surgery: Lessons from our Practice
  • Gamma Knife: Lessons from our Practice
  • LASER options: Lessons from our Practice
  • Focus Ultrasound: Lessons from our Practice
  • Thermocoagulation: Lessons from our Practice
• Development of an HH Research Roadmap

Registration Information

To register for the Symposium, click here.

Fees (include sessions, lunch, and refreshments):

• 150 EUR
• 100 EUR (Young Investigators – working in an epilepsy clinic or research setting)

Hotel:
A limited number of accommodations have been reserved at Abba Garden Hotel. Contact the hotel directly by emailing, Mrs. Alba Perez (garden@abbahoteles.com). When making your reservation, please mention “HOPE FOR HH symposium participant” to benefit from the negotiated rates.

 

For more information regarding registration, please contact Manon Palou at hope-hh2025@ant-congres.com

Call for Abstracts

SUBMISSION DEADLINE : May 19, 2025 – 23h59 CET time zone.

Abstracts must be submitted via the online submission here.

• Presentation form: Abstracts must be submitted for oral communications only.
• Abstract/Presentation Language: All abstract submissions should be in English.
• Character Limit: The abstract text must be no more than 500 words including title and authors’ information and must include the following four areas: Introduction / Methods / Results / Conclusions.
• Do not use charts, graphs, or tables.
• Encore abstracts will not be accepted.

We will only be accepting original data on Fundamental Research; results from clinical trials; diagnostic and treatment practices. The number of accepted abstracts is limited to 8 oral communications, to be presented in-person during Session 3, “Learning from Clinicians and Researchers” to be held on Thursday, September 4th, 2025. The registrations fees of the presenting author will be waived.

Scholarships for Young Investigators

To encourage young investigators to pursue Hypothalamic Hamartoma Syndrome as an area of practice and research, a limited number of scholarships are available to assist with registration, travel and hotel costs. Investigators are eligible if they are actively enrolled in a doctoral program, residence or accredited program of postgraduate education in neurosciences or are a new faculty (at or below the rank of Associate Professor). Priority will be given to women, racial/ethnic minorities and persons with disabilities. To be considered, submit the information below in a single email to Manon Palou at hope-hh2025@ant-congres.com. Please include “6th International HH Symposium Scholarship Request” in the subject line. The deadline is May 30, 2025. Awards to be confirmed by June 30, 2025.

1. Curriculum vitae or National Institutes of Health biosketch including list of publications – limit 5 pages
2. Narrative statement regarding the importance of your attendance at the Symposium for current and future work – limit 500 words
3. One letter of support from your current research mentor that includes their name, position, contact information, and email.

Invited Faculty and Chairs

Organizers

Partners

Endorsed

Sponsors